What size range and structures can SAXS (Small-Angle X-ray Scattering) probe?

SAXS is sensitive to structural features roughly between 1 and 100 nanometers, making it well suited to nanoparticles, protein aggregates, liposomes, micelles, and other nanostructured or self-assembled systems within that size window.

Does SAXS require my sample to be crystalline?

No — unlike X-ray diffraction (XRD), SAXS does not require crystalline order and works equally well on amorphous, disordered or partially ordered nanostructures, since it probes overall size, shape and spatial organization rather than atomic-lattice periodicity.

Can SAXS analyze samples in solution, or only solids?

SAXS is routinely performed on samples in solution, which is one of its key advantages — it allows nanoparticles, proteins and self-assembled systems to be studied in a near-native, solvated state rather than requiring drying or other preparation that could alter the structure being measured.

How does SAXS compare to dynamic light scattering (DLS) for particle sizing?

Both measure particles in solution, but SAXS derives size and shape information directly from X-ray scattering intensity as a function of angle, offering more detailed structural information (such as radius of gyration and internal structure) than DLS, which primarily reports a hydrodynamic size based on particle diffusion and is generally faster and lower-cost for simple size distributions.

Is SAXS a destructive technique?

No — SAXS is non-destructive under standard measurement conditions, and the sample can typically be recovered or reused afterward, though prolonged X-ray exposure should be considered for radiation-sensitive biological samples.

SAXS

小角X線散乱

材料のナノメートルサイズ構造と分子組織の特性評価。

Solicitar relatório →← Voltar à x-ray analysis

O que é SAXS

Uma técnica de análise avançada

材料のナノメートルサイズ構造と分子組織の特性評価。

SensibilidadeAlta

Estado da amostraVariável

私たちの違い

スペクトルだけをお渡しすることはありません。お渡しするのは解釈です。

どの検査機関でもピークと数値は返せます。私たちの報告書はデータを読み解きます。私たちが提供する価値を決定づける3つの違いを、匿名化した実際の事例で以下にご紹介します。

複数の分析技術を、1つの統合された報告書に

バラバラの5つの報告書をお渡しすることはありません。すべての分析技術の結果を突き合わせ、各シグナルを他と照合したうえで、単一の解釈にまとめ上げます — データの山ではなく、答えにたどり着くためです。

汚染調査 — 異物の由来を特定し追跡する。
性能劣化 — ロットが想定外の挙動を示す理由を説明する。
新規サプライヤーの検証 — 切り替え前に同等性を証明する。

分析結果の収束・実際の事例1つが不一致：NMR

FTIR赤外分光法

同等

FTラマンラマン散乱

同等

XRDX線回折

同等

XRF蛍光X線分析

同等

固体¹³C NMR核磁気共鳴・固体状態

差異を検出

LDPE 3ロット · 4技術が一致し、NMRのみが差異を明らかに

4. 実験的根拠

半結晶性ポリマー系では、加工時の熱力学的変数が鎖のコンフォメーション動態に影響します¹。固体NMRはナノメートルスケールの化学的環境を分解でき²、XRDやFTIRでは検出できない変化にも感度を示します³。

参考文献

1Muller et al. (2015). Polymer Testing, 45, 112–120.

2Schmidt-Rohr & Spiess (1994). Multidimensional Solid-State NMR.

3Korbi et al. (2025). J. Appl. Polym. Sci., 142, e5531.

文献に裏付けられた技術的根拠

報告書における技術選択と推論はすべて、査読済み文献に基づき、本文中に引用を明記しています。結論は単なる意見ではなく、監査でもお客様への説明でも通用する、追跡可能な論拠です。

主張と出典を結びつける番号付き引用
分析対象ごとに参照される公式規格・方法
最初から最後まで検証可能な論理展開

結論と専門家の見解

報告書は主任研究員が署名する明確な見解で締めくくられます — データが示すこと、まだ断定できないこと、そして次のステップです。推論の限界についても正直に注記しており、これが単なる推測と技術的見解を分けるポイントです。

結果だけでなく明確な技術的見解を提示
推論の限界を正直に明記
主任研究員(P.I.)署名による次のステップの提案

8. 結論

4つの技術が同等性を確認しましたが、 固体NMRのみ が、従来のQCでは判別できない微妙なコンフォメーション変化を明らかにしました — これはろ過挙動の異常と一致する分子シグネチャです。

工業ラインのパラメータがないため、直接的な因果関係は特定できません — 解明のための追加調査を推奨します。

Dr. ██████████主任研究員 · CRQ 381965

署名済み

Aplicações de mercado

Onde a SAXS entrega resultados

市場応用

ファーマ

医薬品ナノ製剤の特性評価
制御放出システムの解析
API分子組織の研究

材料

ナノ材料の特性評価
ポリマー構造解析
超分子組織の研究

化粧品

化粧品ナノエマルションの解析
ミセルシステムの特性評価
脂質組織の研究

FAQ

Frequently Asked Questions about Small-Angle X-ray Scattering (SAXS)

What size range and structures can SAXS (Small-Angle X-ray Scattering) probe?: SAXS is sensitive to structural features roughly between 1 and 100 nanometers, making it well suited to nanoparticles, protein aggregates, liposomes, micelles, and other nanostructured or self-assembled systems within that size window.
Does SAXS require my sample to be crystalline?: No — unlike X-ray diffraction (XRD), SAXS does not require crystalline order and works equally well on amorphous, disordered or partially ordered nanostructures, since it probes overall size, shape and spatial organization rather than atomic-lattice periodicity.
Can SAXS analyze samples in solution, or only solids?: SAXS is routinely performed on samples in solution, which is one of its key advantages — it allows nanoparticles, proteins and self-assembled systems to be studied in a near-native, solvated state rather than requiring drying or other preparation that could alter the structure being measured.
How does SAXS compare to dynamic light scattering (DLS) for particle sizing?: Both measure particles in solution, but SAXS derives size and shape information directly from X-ray scattering intensity as a function of angle, offering more detailed structural information (such as radius of gyration and internal structure) than DLS, which primarily reports a hydrodynamic size based on particle diffusion and is generally faster and lower-cost for simple size distributions.
Is SAXS a destructive technique?: No — SAXS is non-destructive under standard measurement conditions, and the sample can typically be recovered or reused afterward, though prolonged X-ray exposure should be considered for radiation-sensitive biological samples.

Vamos conversar

Precisa de uma análise por SAXS?

Compartilhe seu desafio analítico e a nossa equipe define o método, o preparo de amostra e o escopo do relatório.

Solicitar orçamento →